Oral 5-aminosalicylic acid for inflammatory bowel disease in pregnancy: safety and clinical course

Gastroenterology. 1993 Oct;105(4):1057-60. doi: 10.1016/0016-5085(93)90949-d.


Background: Oral 5-aminosalicylic acid (5-ASA) has proven an effective maintenance therapy of ulcerative colitis and may also be useful in Crohn's disease, but its safety in pregnancy has not been established. The present study therefore examined the course and outcome of pregnancies in patients with inflammatory bowel disease who continued to take oral 5-ASA.

Methods: Ten patients with ulcerative colitis and 7 patients with Crohn's disease with a total of 19 pregnancies were studied while they were receiving 5-ASA. All patients were previously in remission on 5-ASA, at a mean dose of 1.7 g/day (range, 0.8-2.4 g/day). They continued taking the drug without a change in dose and were followed up throughout their pregnancies and postpartum.

Results: Eighteen pregnancies resulted in full-term delivery. No fetal abnormalities were found at delivery, and there were no clinical or biochemical abnormalities in the neonatal period. Four patients had a relapse. One patient required a colectomy but carried on to a full-term pregnancy. One patient had a miscarriage, but she had miscarried on four previous occasions before taking 5-ASA. She subsequently had a successful pregnancy on 5-ASA.

Conclusions: Oral 5-ASA appears to be safe for the management of inflammatory bowel disease during pregnancy.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Aminosalicylic Acid / administration & dosage*
  • Aminosalicylic Acid / standards
  • Aminosalicylic Acid / therapeutic use
  • Colitis, Ulcerative / drug therapy*
  • Crohn Disease / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Pregnancy Outcome


  • Aminosalicylic Acid