Cloning and characterization of human TNF alpha promoter region

Gene. 1993 Sep 15;131(2):307-8. doi: 10.1016/0378-1119(93)90314-s.

Abstract

We report the sequence of a 1.2-kb human tumor necrosis factor alpha (TNF alpha) promoter region, which was cloned using PCR. The sequence has several variations from two previous reports and exhibits many potential DNA-binding sites specific to mammalian gene regulatory proteins inducible by lipopolysaccharides.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • DNA
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Promoter Regions, Genetic*
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • Tumor Necrosis Factor-alpha
  • DNA

Associated data

  • GENBANK/L11698
  • GENBANK/L13267
  • GENBANK/L13268
  • GENBANK/L24523
  • GENBANK/L24524
  • GENBANK/L24525
  • GENBANK/L24526
  • GENBANK/L24527
  • GENBANK/L24528
  • GENBANK/L24529