Proton magnetic resonance spectroscopy of vitreal changes in experimental streptococcal endophthalmitis

Graefes Arch Clin Exp Ophthalmol. 1993 Jul;231(7):402-4. doi: 10.1007/BF00919648.


We used magnetic resonance spectroscopy to examine endophthalmitis in rabbits inoculated with a virulent strain of Streptococcus pneumoniae. On different days after infection, the animals were sacrificed and the vitreous isolated and examined with water-suppressed proton magnetic resonance spectroscopy. A broad resonance corresponding to the methyl envelope of lipoprotein lipids appeared 2 days after infection and persisted until the eyes developed phthisis (around 10 days postinfection). This resonance was absent in the control eye and the bacterial culture; it could be used as the marker of breakdown of blood-vitreous barrier and onset of endophthalmitis-induced changes.

MeSH terms

  • Animals
  • Biomarkers
  • Disease Models, Animal
  • Endophthalmitis / metabolism*
  • Endophthalmitis / microbiology
  • Eye Infections, Bacterial / metabolism*
  • Magnetic Resonance Spectroscopy
  • Pneumococcal Infections / metabolism*
  • Rabbits
  • Vitreous Body / metabolism*


  • Biomarkers