High incidence of Epstein-Barr virus detection in Hodgkin's disease and absence of detection in anaplastic large-cell lymphoma in children

Histopathology. 1993 Aug;23(2):189-91. doi: 10.1111/j.1365-2559.1993.tb00480.x.

Abstract

By in situ hybridization with EBER oligonucleotides and immunohistochemistry with anti-latent membrane protein 1 (LMP1) antibody, we compared the detection rate of Epstein-Barr virus (EBV) in Hodgkin's disease and anaplastic large-cell lymphomas in children. Among the 13 cases of Hodgkin's disease tested, 7 (54%) were found to be EBV associated (EBER transcripts +, LMP1 +). None of the 11 cases of ALC lymphomas was found to contain EBV genomes or gene products. This may indicate that EBV is not a pathogenic agent in anaplastic large-cell lymphomas in children in comparison to Hodgkin's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Herpesvirus 4, Human / isolation & purification*
  • Hodgkin Disease / microbiology*
  • Hodgkin Disease / pathology
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymphoma, Large B-Cell, Diffuse / microbiology*
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Tumor Virus Infections / pathology*