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. 1993 Nov;61(11):4899-901.

Endogenous Gamma Interferon Mediates Resistance to Brucella Abortus Infection

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Free PMC article

Endogenous Gamma Interferon Mediates Resistance to Brucella Abortus Infection

Y Zhan et al. Infect Immun. .
Free PMC article

Abstract

Depletion of endogenous gamma interferon (IFN-gamma) with anti-IFN-gamma monoclonal antibody resulted in increased numbers of Brucella abortus in the spleen and liver of infected CBA mice. This increase was accompanied by a decrease in splenomegaly and a lower proportion of macrophages in the spleen. Furthermore, treatment of recipient mice with anti-IFN-gamma antibody blocked the adoptive transfer of resistance with immune T cells. Together, the results indicated that endogenous IFN-gamma plays an important role in mediating resistance to primary and secondary Brucella infection.

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