Abstract
The pharmacokinetics of antidepressants are reviewed with special emphasis on clinical applicability. There are substantial pharmacokinetic differences among the five major classes. Pharmacokinetic differences between members of a specific class are usually modest except for serotonin selective reuptake inhibitors. Between members of this class pharmacokinetic differences are the major distinguishing variables and have clinically important consequences.
MeSH terms
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Antidepressive Agents / pharmacokinetics*
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Antidepressive Agents / pharmacology
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Antidepressive Agents / therapeutic use
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Antidepressive Agents, Tricyclic / pharmacokinetics
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Antidepressive Agents, Tricyclic / pharmacology
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Antidepressive Agents, Tricyclic / therapeutic use
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Biological Availability
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Bupropion / pharmacokinetics
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Bupropion / pharmacology
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Bupropion / therapeutic use
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Depressive Disorder / drug therapy*
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Drug Monitoring
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Half-Life
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Humans
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Monoamine Oxidase Inhibitors / pharmacokinetics
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Monoamine Oxidase Inhibitors / pharmacology
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Monoamine Oxidase Inhibitors / therapeutic use
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Selective Serotonin Reuptake Inhibitors / pharmacokinetics
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Selective Serotonin Reuptake Inhibitors / pharmacology
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Selective Serotonin Reuptake Inhibitors / therapeutic use
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Trazodone / pharmacokinetics
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Trazodone / pharmacology
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Trazodone / therapeutic use
Substances
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Antidepressive Agents
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Antidepressive Agents, Tricyclic
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Monoamine Oxidase Inhibitors
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Serotonin Uptake Inhibitors
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Bupropion
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Trazodone