Repeated aspiration of ovarian follicles and early corpus luteum cysts in an in-vitro fertilization programme reduces the risk of ovarian hyperstimulation syndrome in high responders

Hum Reprod. 1993 Aug;8(8):1184-6. doi: 10.1093/oxfordjournals.humrep.a138225.


A retrospective analysis of ovarian hyperstimulation syndrome in high responders undergoing in-vitro fertilization (IVF) is presented. High responders were defined as having > 20 follicles and serum oestradiol > 3000 pg/ml after treatment with human menopausal gonadotrophin. Of the initial 30 IVF cycles in high responders, 23 developed a moderate-to-severe ovarian hyperstimulation syndrome (76.7%). Subsequently, 15 other IVF cycles in high responders were combined with a repeated aspiration of ovarian follicles and corpus luteum cysts just prior to embryo transfer. Only three patients (20%) developed a moderate ovarian hyperstimulation syndrome (P = 0.0004). We conclude that repeated follicular aspiration is safe and results in a significant reduction in the incidence and severity of this condition in high responders undergoing IVF.

MeSH terms

  • Adult
  • Chorionic Gonadotropin / therapeutic use
  • Corpus Luteum / surgery*
  • Estradiol / blood
  • Female
  • Fertilization in Vitro*
  • Humans
  • Menotropins / administration & dosage
  • Menotropins / therapeutic use
  • Ovarian Follicle / surgery*
  • Ovarian Hyperstimulation Syndrome / etiology
  • Ovarian Hyperstimulation Syndrome / prevention & control*
  • Ovulation Induction / adverse effects
  • Risk Factors
  • Suction


  • Chorionic Gonadotropin
  • Estradiol
  • Menotropins