In utero acute graft-versus-host disease in a neonate with severe combined immunodeficiency

J Am Acad Dermatol. 1993 Nov;29(5 Pt 2):862-5. doi: 10.1016/0190-9622(93)70257-t.


We describe a male neonate with severe combined immunodeficiency who at birth had acute graft-versus-host disease (GVHD) as a result of maternal-fetal transfusion during pregnancy. Several clinical signs helped establish this diagnosis. Findings of a skin biopsy specimen confirmed the diagnosis of acute GVHD. Immunologic evaluation disclosed an absence of T and B lymphocytes. Acute GVHD in severe combined immunodeficiency most often occurs during the first weeks of life; intrauterine occurrence is unusual.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Dermatitis, Exfoliative / etiology
  • Female
  • Fetomaternal Transfusion / complications*
  • Graft vs Host Disease / etiology*
  • Graft vs Host Disease / pathology
  • Humans
  • Infant, Newborn
  • Male
  • Pregnancy
  • Severe Combined Immunodeficiency / complications
  • Severe Combined Immunodeficiency / congenital*
  • Skin / pathology