Antigen identification in drug-induced bullous pemphigoid

J Am Acad Dermatol. 1993 Nov;29(5 Pt 2):879-82. doi: 10.1016/0190-9622(93)70262-r.


Immunobullous diseases usually develop spontaneously, but drug-induced bullous disease develops in a small subgroup of patients. We examined a patient in whom bullous pemphigoid developed after she received enalapril for treatment of hypertension. IgG antibody directed against a 230 kd antigen was identified. The eluted IgG autoantibody was shown to bind to the basement membrane zone on split skin. This study demonstrates that drug-induced bullous pemphigoid autoantibody in this patient was directed against the same antigen as the spontaneous bullous pemphigoid antigen.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Antigens / analysis*
  • Dapsone / administration & dosage
  • Enalapril / adverse effects*
  • Female
  • Humans
  • Hypertension / drug therapy
  • Pemphigoid, Bullous / chemically induced*
  • Pemphigoid, Bullous / immunology*


  • Antigens
  • Enalapril
  • Dapsone