Methotrexate and reproduction in men: case report and recommendations

J Am Acad Dermatol. 1993 Nov;29(5 Pt 2):913-6. doi: 10.1016/0190-9622(93)70270-4.


Methotrexate has been used in the treatment of recalcitrant psoriasis for more than 35 years. We examined the significance of impaired spermatogenesis in a young man undergoing methotrexate treatment for severe psoriasis with associated arthritis. A medical geneticist was consulted and a review of the literature was performed. Genetic abnormalities that could lead to mutagenesis include chromosomal abnormalities and single-gene mutations. These aspects are considered and recommendations are made for counseling men undergoing methotrexate therapy so that risks and options can be considered.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Arthritis / complications
  • Chromosome Aberrations / chemically induced
  • Chromosome Disorders
  • Genetic Counseling*
  • Humans
  • Male
  • Methotrexate / adverse effects*
  • Mutation
  • Psoriasis / complications
  • Psoriasis / drug therapy
  • Psoriasis / genetics
  • Spermatogenesis / drug effects*


  • Methotrexate