Indications for the sclerosing agent polidocanol (aetoxisclerol dexo, aethoxisklerol kreussler)

J Dermatol Surg Oncol. 1993 Oct;19(10):959-61. doi: 10.1111/j.1524-4725.1993.tb00985.x.


Background: Polidocanol is a widely used sclerosing agent that was first developed as a local anesthetic. In France it is used in varicose veins as well as in telangiectases.

Objective: To improve the knowledge of the effects of polidocanol and provide recommendations for better use.

Methods: Based on 12 years of experience in treating nearly 11,000 patients with polidocanol, the author reviews his observations. A theoretical model of dilution of sclerosing agents in injected veins is provided.

Results: The author observed: seven cases of minor urticaria, occurrence of grey veil when used under the air-block technique, one case of cutaneous necrosis (5 cm3), and some small epidermic necrosis (1-mm diameter) and neither shock nor severe adverse reaction.

Conclusion: Polidocanol is characterized by its spasmogenic action on veins, excellent local tolerance, and a very low incidence of general reactions. Low concentrations (0.3 to 0.6%) can be used for the treatment of quite large varicose veins if an adequate volume is injected.

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Necrosis / chemically induced
  • Polidocanol
  • Polyethylene Glycols / administration & dosage*
  • Polyethylene Glycols / adverse effects
  • Sclerosing Solutions / administration & dosage*
  • Sclerotherapy / adverse effects
  • Skin / pathology
  • Urticaria / chemically induced
  • Varicose Veins / therapy*


  • Sclerosing Solutions
  • Polidocanol
  • Polyethylene Glycols