Pruritus associated with allergic skin diseases is an important reason for consultation in feline medicine. The pathophysiology of pruritus is poorly understood in the cat, but histamine and eicosanoids appear to be important mediators. The medical management of allergic pruritus in cats, especially those with atopy, using glucocorticoids, antihistamines, omega-3/omega-6 fatty acid-containing products, and combinations thereof is discussed.