Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 37 (2), 204-10

Phylogenetic Relationships of HMG Box DNA-binding Domains

Comparative Study

Phylogenetic Relationships of HMG Box DNA-binding Domains

E A Griess et al. J Mol Evol.


HMG boxes were initially identified as DNA-binding domains of the human RNA polymerase I (pol I) transcription factor hUBF and the animal high-mobility-group (HMG) protein family HMG1. Since then, numerous sequences of HMG-box-containing HMG proteins and other DNA-binding proteins from several species have become available. By sequence comparisons of a selected range of HMG boxes from these proteins and the construction of phylogenetic trees we show that the HMG box is highly conserved between DNA-binding proteins of organisms from all three eukaryotic kingdoms and that HMG boxes are linked by distinct evolutionary relationships. In addition, most HMG boxes display comparable hydropathy profiles and amino acid arrangements, which could serve as nuclear targeting sequences.

Similar articles

See all similar articles

Cited by 12 PubMed Central articles

See all "Cited by" articles


    1. Nature. 1990 Apr 26;344(6269):830-6 - PubMed
    1. Nucleic Acids Res. 1991 May 25;19(10):2573-7 - PubMed
    1. Science. 1991 May 17;252(5008):965-9 - PubMed
    1. EMBO J. 1992 Mar;11(3):1055-63 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Apr;85(8):2444-8 - PubMed

Publication types


LinkOut - more resources