Overwhelming pulmonary blastomycosis associated with the adult respiratory distress syndrome

N Engl J Med. 1993 Oct 21;329(17):1231-6. doi: 10.1056/NEJM199310213291704.


Background and methods: Few cases of overwhelming pulmonary blastomycosis associated with the adult respiratory distress syndrome have been reported. We describe 10 patients with this condition who were treated at one center in Wisconsin.

Results: All 10 patients presented with fever, cough, and dyspnea; radiographic evidence of diffuse pulmonary infiltrates; and marked impairment of oxygenation. The mean alveolar-arterial oxygen gradient was 616 mm Hg. Six of the patients had no underlying disease associated with altered immunity, and two had no recent exposure to environmental reservoirs of Blastomyces dermatitidis. In all 10 patients, large numbers of broad-based budding yeasts were seen on microscopical examination of tracheal secretions. All patients were treated with intravenous amphotericin B (0.7 to 1.0 mg per kilogram per day). Of the five survivors, four received full doses of amphotericin B in the first 24 hours, and four required mechanical ventilatory support for 7 to 151 days. Long-term follow-up of three survivors showed good recovery of pulmonary function.

Conclusions: Overwhelming infection with B. dermatitidis can cause diffuse pneumonitis and the adult respiratory distress syndrome, even in immunocompetent hosts. With prompt diagnosis by microscopical examination of tracheal secretions, intensive therapy with amphotericin B, and ventilatory support, good recovery of pulmonary function is possible.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Amphotericin B / therapeutic use
  • Blastomycosis / complications*
  • Blastomycosis / diagnosis
  • Blastomycosis / drug therapy
  • Blastomycosis / physiopathology
  • Female
  • Follow-Up Studies
  • Humans
  • Lung Diseases, Fungal / complications*
  • Lung Diseases, Fungal / physiopathology
  • Male
  • Middle Aged
  • Pneumonia / complications*
  • Pneumonia / diagnosis
  • Pneumonia / drug therapy
  • Pneumonia / physiopathology
  • Respiratory Distress Syndrome, Adult / etiology*
  • Respiratory Distress Syndrome, Adult / physiopathology


  • Amphotericin B