New roles for G-protein beta gamma-dimers in transmembrane signalling

Nature. 1993 Sep 30;365(6445):403-6. doi: 10.1038/365403a0.


When a membrane-bound receptor acts on a G protein, the GTP-binding or G alpha subunit dissociates from the G beta gamma dimer. Until recently, the G alpha subunit alone was thought to act on the enzymes and ion channels controlled by these proteins. Newer evidence indicates that the G beta gamma dimer also plays a major part in signal transmission, enhancing the complexity of the possible interactions between the G proteins and their targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • GTP-Binding Proteins / physiology*
  • Signal Transduction*


  • GTP-Binding Proteins