The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

Nature. 1993 Oct 14;365(6447):644-9. doi: 10.1038/365644a0.

Abstract

The bone morphogenetic protein (BMP) family is a conserved group of signalling molecules within the transforming growth factor-beta (TGF-beta) superfamily. This group, including the Drosophila decapentaplegic (dpp) protein and the mammalian BMPs, mediates cellular interactions and tissue differentiation during development. Here we show that a homologue of human BMPs controls a developmental switch in the life cycle of the free-living soil nematode Caenorhabditis elegans. Starvation and overcrowding induce C. elegans to form a developmentally arrested, third-stage dauer larva. The daf-4 gene, which acts to inhibit dauer larva formation and promote growth, encodes a receptor protein kinase similar to the daf-1, activin and TGF-beta receptor serine/threonine kinases. When expressed in monkey COS cells, the daf-4 receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Animals, Genetically Modified
  • Base Sequence
  • Bone Morphogenetic Proteins
  • Caenorhabditis elegans / enzymology
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / growth & development
  • Caenorhabditis elegans Proteins*
  • Cell Line
  • DNA
  • DNA Transposable Elements
  • Growth / genetics
  • Haplorhini
  • Helminth Proteins / genetics
  • Helminth Proteins / metabolism*
  • Humans
  • Larva / genetics
  • Larva / growth & development
  • Molecular Sequence Data
  • Protein Binding
  • Protein-Serine-Threonine Kinases / genetics*
  • Proteins / genetics*
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Receptors, Transforming Growth Factor beta*
  • Recombinant Proteins
  • Sequence Homology, Amino Acid

Substances

  • Bone Morphogenetic Proteins
  • Caenorhabditis elegans Proteins
  • DNA Transposable Elements
  • Helminth Proteins
  • Proteins
  • Receptors, Transforming Growth Factor beta
  • Recombinant Proteins
  • daf-4 protein, C elegans
  • DNA
  • Receptor Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases

Associated data

  • GENBANK/L23110