[Local injection treatment with botulinum toxin A in severe arm and leg spasticity]

Nervenarzt. 1993 Aug;64(8):517-23.
[Article in German]


In patients with predominantly focal spasticity, oral antispastic drugs are relatively ineffective or cause unwanted side effects of central origin. Therefore we treated patients disabled by focal spasticity with local injections of Botulinum-Toxin A (Porton Products BOTOX). Efficacy, dosage, side-effects and injection technique were examined. 11 patients (mean age 48 years) with severe focal spasticity of the flexor muscles of the hand and arm (5 patients), the adductor muscles of the legs (5) or the plantar flexors of the foot (1) due to multiple sclerosis, cervical myelopathy or stroke-related hemi-paresis were treated with BOTOX. Rating scales, including Ashford spasticity scale, pain scale and a hygienic rating scale, were used to evaluate the efficacy. 25 to 30 ng (1000-1200 MU Porton) were injected in the flexor group of the hand or arm and 42 to 50 ng (1680-2000 MU Porton) BOTOX in the adductor group of one leg. 10 of the patients showed an improvement of at least one point on the scales for spasticity, pain and hygiene. Effects could be observed after 4-7 days and lasted for 6-13 weeks. There were no unwanted side-effects. We conclude that BOTOX is an alternative to the systemic application of antispastic drugs. Focal spasticity and pain can be successfully reduced and hygienic care is facilitated.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Arm / innervation
  • Botulinum Toxins / administration & dosage*
  • Central Nervous System Diseases / drug therapy*
  • Contracture / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Foot Deformities, Acquired / drug therapy*
  • Hand Deformities, Acquired / drug therapy*
  • Humans
  • Injections, Intramuscular
  • Leg / innervation
  • Male
  • Middle Aged
  • Muscle Spasticity / drug therapy*
  • Muscles / innervation


  • Botulinum Toxins