Pattern of interleukins in minimal-change nephrotic syndrome of childhood

Nephron. 1993;65(1):56-61. doi: 10.1159/000187441.

Abstract

Assays of interleukin-1 (IL-1) and IL-2 were done in supernatants from phytohaemagglutinin-activated lymphocyte cultures from 10 children suffering from minimal-change nephrotic syndrome (MCNS) to assess their role in the aetiopathogenesis of this disorder. Increased levels of IL-1 and IL-2 had been found in supernatants from patients having MCNS compared with controls, suggesting a significant role of these cytokines in the immunopathogenesis of proteinuria in this syndrome.

MeSH terms

  • Child
  • Child, Preschool
  • Female
  • Humans
  • In Vitro Techniques
  • Infant
  • Interleukin-1 / biosynthesis*
  • Interleukin-2 / biosynthesis*
  • Lymphocyte Activation
  • Male
  • Nephrosis, Lipoid / complications
  • Nephrosis, Lipoid / immunology*
  • Proteinuria / etiology
  • T-Lymphocytes / immunology

Substances

  • Interleukin-1
  • Interleukin-2