A model for in utero endoscopic treatment of myelomeningocele

Neurosurgery. 1993 Sep;33(3):542-4; discussion 545. doi: 10.1227/00006123-199309000-00043.

Abstract

An animal model for intrauterine surgical treatment of myelomeningocele is described using sheep. We report the technical feasibility of endoscopic intrauterine skin graft placement over surgically induced defects, including over exposed spinal cord. These grafts exclude amniotic fluid from the underlying lesion and provide a matrix for fetal skin growth below the graft. The potential for human application is discussed.

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Female
  • Fetal Diseases / pathology
  • Fetal Diseases / surgery*
  • Hysteroscopes*
  • Meningomyelocele / pathology
  • Meningomyelocele / surgery*
  • Pregnancy
  • Sheep
  • Skin / pathology
  • Skin Transplantation / pathology
  • Wound Healing / physiology