Antecedent clinical features associated with dementia in Parkinson's disease

Neurology. 1993 Sep;43(9):1690-2. doi: 10.1212/wnl.43.9.1690.

Abstract

In a prospective cohort study, we examined clinical features in 250 nondemented patients with idiopathic Parkinson's disease (PD) and then evaluated their association with incident dementia during 5 years of follow-up. Seventy-four of the patients became demented. Odds ratios for incident dementia with PD were increased for the following: being older than 70 years of age (2.7; 1.4 to 5.5), having a PD rating scale score greater than 25 (3.0; 1.5 to 6.2), being depressed (2.7; 1.5 to 6.6), being confused or psychotic on levodopa (3.3; 1.3 to 8.7), or having facial masking as a presenting sign (6.1; 1.4 to 26.9).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Dementia / epidemiology*
  • Dementia / etiology
  • Depression / chemically induced
  • Depression / epidemiology
  • Humans
  • Levodopa / adverse effects
  • Middle Aged
  • Odds Ratio
  • Parkinson Disease / complications
  • Parkinson Disease / drug therapy
  • Parkinson Disease / epidemiology*
  • Prevalence
  • Psychoses, Substance-Induced / epidemiology
  • Risk Factors

Substances

  • Levodopa