Heparin vs. saline for peripheral i.v. locks in children

Pediatr Nurs. 1993 Jul-Aug;19(4):405-9, 376.


Purpose: To determine the efficacy of saline versus heparin flush solution to maintain peripheral i.v. locks in a pediatric population.

Method: A prospective, randomized, double-blind design was used. A sample of 124 peripheral i.vs. were flushed with either saline or heparin in saline. Subjects were infants over 28 days of age and children.

Findings: The heparin and saline groups were comparable for total hours duration of the i.v. and for incidence of complications.

Conclusions: Saline is efficacious in maintaining patency of peripheral i.v. locks in children over 28 days of age.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Catheterization, Peripheral / nursing*
  • Child
  • Child, Preschool
  • Clinical Nursing Research
  • Double-Blind Method
  • Heparin / administration & dosage*
  • Humans
  • Infant
  • Prospective Studies
  • Sodium Chloride / administration & dosage*
  • Vascular Patency


  • Sodium Chloride
  • Heparin