Effects of rice bran hemicellulose on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in Fischer 344 rats

Nutr Cancer. 1993;20(1):41-9. doi: 10.1080/01635589309514269.

Abstract

The effect of rice bran hemicellulose (RBH) on 1,2-dimethylhydrazine- (DMH) induced intestinal carcinogenesis was studied in male Fischer 344 rats. Rats were fed a basal control diet or a diet containing 2% or 4% RBH at five weeks of age. At 6 weeks of age, all animals were given an intraperitoneal injection of DMH (20 mg/kg body wt) at weekly intervals for 20 weeks and autopsied 7 weeks after the last injection. The incidence of DMH-induced colon tumors was significantly lower in rats fed the 4% RBH diet than in rats fed the basal control diet (p < 0.05). The number of colon tumors per rat was also significantly lower in rats fed the 4% RBH diet than in rats fed the basal control diet (p < 0.05). The present study suggested that the water-soluble RBH played a preventive role in DMH-induced large bowel carcinogenesis in Fischer 344 rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1,2-Dimethylhydrazine
  • Acids / analysis
  • Animals
  • Body Weight / physiology
  • Carcinogens
  • Cecum / chemistry
  • Dimethylhydrazines
  • Hydrogen-Ion Concentration
  • Incidence
  • Intestinal Neoplasms / chemically induced
  • Intestinal Neoplasms / diet therapy*
  • Male
  • Oryza*
  • Polysaccharides / pharmacology*
  • Rats
  • Rats, Inbred F344

Substances

  • Acids
  • Carcinogens
  • Dimethylhydrazines
  • Polysaccharides
  • hemicellulose
  • 1,2-Dimethylhydrazine