ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias

Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8977-81. doi: 10.1073/pnas.90.19.8977.

Abstract

ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemical carcinogenesis than are +/+ mammary glands. Transplantation of mammary cells from Min/+ or +/+ donors into +/+ hosts demonstrates that the propensity to develop mammary tumors is intrinsic to the Min/+ mammary cells. Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / toxicity
  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology
  • Animals
  • Crosses, Genetic
  • Ethylnitrosourea / toxicity
  • Female
  • Genes, APC*
  • Genetic Predisposition to Disease
  • Hyperplasia
  • Male
  • Mammary Glands, Animal / pathology*
  • Mammary Neoplasms, Animal / genetics*
  • Mammary Neoplasms, Animal / pathology
  • Mammary Neoplasms, Experimental / chemically induced
  • Mammary Neoplasms, Experimental / genetics
  • Mammary Neoplasms, Experimental / pathology
  • Metaplasia
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Point Mutation*

Substances

  • 9,10-Dimethyl-1,2-benzanthracene
  • Ethylnitrosourea