Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia

Am J Clin Nutr. 1993 Jan;57(1):47-53. doi: 10.1093/ajcn/57.1.47.

Abstract

We measured the vitamin B-6, vitamin B-12, and folic acid nutritional status in a group of apparently healthy men (n = 44) with moderate hyperhomocysteinemia (plasma homocysteine concentration > 16.3 mumol/L). Compared with control subjects (n = 274) with normal plasma homocysteine (< or = 16.3 mumol/L) concentrations, significantly lower plasma concentrations of pyridoxal-5'-phosphate (P < 0.001), cobalamin (P < 0.001), and folic acid (P = 0.004) were demonstrated in hyperhomocysteinemic men. The prevalence of suboptimal vitamin B-6, B-12, and folate status in men with hyperhomocysteinemia was 25.0%, 56.8%, and 59.1%, respectively. In a placebo-controlled follow-up study, a daily vitamin supplement (10 mg pyridoxal, 1.0 mg folic acid, 0.4 mg cyanocobalamin) normalized elevated plasma homocysteine concentrations within 6 wk. Because hyperhomocysteinemia is implicated as a risk factor for premature occlusive vascular disease, appropriate vitamin therapy may be both efficient and cost-effective to control elevated plasma homocysteine concentrations.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cardiovascular Diseases / prevention & control
  • Cystathionine beta-Synthase / deficiency
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Folic Acid / administration & dosage
  • Folic Acid / blood*
  • Folic Acid / therapeutic use
  • Folic Acid Deficiency / complications
  • Follow-Up Studies
  • Homocysteine / blood*
  • Humans
  • Male
  • Middle Aged
  • Pyridoxine / administration & dosage
  • Pyridoxine / blood*
  • Pyridoxine / therapeutic use
  • Vitamin B 12 / administration & dosage
  • Vitamin B 12 / blood*
  • Vitamin B 12 / therapeutic use
  • Vitamin B 12 Deficiency / complications
  • Vitamin B 6 Deficiency / complications

Substances

  • Homocysteine
  • Folic Acid
  • Cystathionine beta-Synthase
  • Pyridoxine
  • Vitamin B 12