The effect of annexin IV and VI on the fluidity of phosphatidylserine/phosphatidylcholine bilayers studied with the use of 5-deoxylstearate spin label

FEBS Lett. 1993 Jan 4;315(2):178-82. doi: 10.1016/0014-5793(93)81158-v.

Abstract

An effect of annexin IV and VI on the fluidity of phosphatidylserine/phosphatidylcholine (PS/PC) membranes was studied by spin labeling technique with the use of 5-doxylstearic acid. It was found that calcium ions at micromolar concentrations induced a marked decrease in the order parameter of PS/PC membranes. This effect was completely abolished by both annexins. The influence of annexins on the mobility of fatty acid chains in the studied region in PE/PC membranes was insignificant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Annexin A4 / chemistry*
  • Annexin A6 / chemistry*
  • Calcium / chemistry
  • In Vitro Techniques
  • Lipid Bilayers
  • Membrane Fluidity
  • Membranes, Artificial
  • Phosphatidylcholines / chemistry*
  • Phosphatidylserines / chemistry*
  • Spin Labels
  • Temperature

Substances

  • Annexin A4
  • Annexin A6
  • Lipid Bilayers
  • Membranes, Artificial
  • Phosphatidylcholines
  • Phosphatidylserines
  • Spin Labels
  • Calcium