Contralateral ovary in unilateral ovarian carcinoma: a search for preneoplastic lesions

Int J Gynecol Pathol. 1993 Jan;12(1):59-63. doi: 10.1097/00004347-199301000-00008.


Contralateral ovaries from patients with unilateral ovarian carcinoma were examined and compared to ovaries from age-matched control patients without ovarian carcinoma. The number of inclusion cysts were increased in ovaries from patients with ovarian carcinoma compared to the controls (p < 0.01). In addition, inclusions from cases with ovarian carcinoma showed serous differentiation more frequently than the controls (p < 0.01; odds ratio = 10.0; 95% confidence interval = 1.2-78.1). An age-related increase in the number of inclusion cysts was seen in the study group but not in the control group. These findings support a role of surface inclusion cysts in the genesis of ovarian carcinoma.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Carcinoma / pathology*
  • Case-Control Studies
  • Female
  • Humans
  • Metaplasia / pathology
  • Middle Aged
  • Neoplasms, Multiple Primary / pathology*
  • Ovarian Cysts / pathology*
  • Ovarian Neoplasms / pathology*
  • Ovary / pathology*
  • Precancerous Conditions / pathology*
  • Retrospective Studies