Immunoglobulin allotypic markers in Kawasaki disease

J Pediatr. 1993 Jan;122(1):84-6. doi: 10.1016/s0022-3476(05)83493-6.

Abstract

We investigated the possible relationship of the distribution of immunoglobulin allotypic markers for susceptibility to Kawasaki disease in Japanese, Japanese-American, and white American populations. The kappa-chain allotype Km1 was present in 25.6% of sera from white patients with Kawasaki disease and in 14.4% of control sera (p < 0.01), and the combination of Km1 with Gm heterozygosity was present in 17.9% of white patients with Kawasaki disease and in 6.4% of control sera (p < 0.0001). In all populations studied, differences were observed between the patients with Kawasaki disease and the race-matched control subjects. The findings support the hypothesis that one or more unknown infectious agents may trigger genetically influenced immune responses that result in clinically recognizable Kawasaki disease.

MeSH terms

  • Adult
  • Alleles
  • Asian Americans / genetics
  • Asian Continental Ancestry Group / genetics
  • Child
  • Disease Susceptibility
  • European Continental Ancestry Group / genetics
  • Genes, Dominant
  • Genetic Markers
  • Heterozygote
  • Humans
  • Immunoglobulin Allotypes / analysis
  • Immunoglobulin Allotypes / genetics*
  • Immunoglobulin Heavy Chains / analysis
  • Immunoglobulin Heavy Chains / genetics
  • Immunoglobulin Light Chains / analysis
  • Immunoglobulin Light Chains / genetics
  • Immunoglobulin alpha-Chains / analysis
  • Immunoglobulin alpha-Chains / genetics
  • Immunoglobulin gamma-Chains / analysis
  • Immunoglobulin gamma-Chains / genetics
  • Immunoglobulin kappa-Chains / analysis
  • Immunoglobulin kappa-Chains / genetics
  • Japan / ethnology
  • Male
  • Mucocutaneous Lymph Node Syndrome / genetics
  • Mucocutaneous Lymph Node Syndrome / immunology*
  • United States

Substances

  • Genetic Markers
  • Immunoglobulin Allotypes
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Light Chains
  • Immunoglobulin alpha-Chains
  • Immunoglobulin gamma-Chains
  • Immunoglobulin kappa-Chains