Potent COMT inhibition by Ro 40-7592 in the periphery and in the brain. Preclinical and clinical findings

Adv Neurol. 1993:60:641-7.
No abstract available

MeSH terms

  • Animals
  • Benserazide / pharmacokinetics
  • Benserazide / pharmacology
  • Benzophenones / pharmacokinetics
  • Benzophenones / pharmacology*
  • Brain / drug effects*
  • Brain / enzymology
  • Carbidopa / pharmacokinetics
  • Carbidopa / pharmacology
  • Catechol O-Methyltransferase / blood
  • Catechol O-Methyltransferase Inhibitors*
  • Dose-Response Relationship, Drug
  • Erythrocytes / drug effects
  • Erythrocytes / metabolism
  • Homovanillic Acid / blood
  • Humans
  • Levodopa / pharmacokinetics
  • Levodopa / pharmacology
  • Male
  • Nitrophenols
  • Peripheral Nerves / drug effects*
  • Peripheral Nerves / enzymology
  • Rats
  • S-Adenosylhomocysteine / pharmacokinetics
  • S-Adenosylmethionine / pharmacokinetics
  • Tolcapone

Substances

  • Benzophenones
  • Catechol O-Methyltransferase Inhibitors
  • Nitrophenols
  • Levodopa
  • Benserazide
  • S-Adenosylmethionine
  • S-Adenosylhomocysteine
  • Tolcapone
  • Catechol O-Methyltransferase
  • Carbidopa
  • Homovanillic Acid