Growth regulation and transformation of ovarian epithelium

Cancer. 1993 Jan 15;71(2 Suppl):545-51. doi: 10.1002/cncr.2820710209.


The discovery of peptide growth factors and cancer-causing genes (oncogenes and tumor-suppressor genes) has provided us with the exciting opportunity to begin to understand the molecular pathology of human ovarian cancer. Activation of several genes, including HER-2/neu, myc, ras, and p53 have been described in some ovarian cancers. In addition, some protooncogenes such as the epidermal growth factor receptor (erbB) and the M-CSF receptor (fms) are expressed along with the respective ligands (peptide growth factors) in some ovarian cancers. Although the studies reviewed in this paper represent a promising beginning, we remain far from a comprehensive understanding of growth regulation and transformation of human ovarian epithelium.

Publication types

  • Review

MeSH terms

  • Cell Division / physiology
  • Cell Transformation, Neoplastic / pathology*
  • Epithelium / pathology
  • Female
  • Humans
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / pathology*
  • Ovary / pathology