Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and Meningococcus polysaccharides

Lancet. 1979 Jan 27;1(8109):190-2. doi: 10.1016/s0140-6736(79)90584-1.


Serum samples were collected from 20 healthy White and 33 Black infants before and after immunisation with three doses of diphtheria-pertussis-tetanus vaccine and with one dose of Haemophilus influenzae type b polyribose phosphate vaccine and meningococcal group A and group C polysaccharide vaccines. Antibodies to these immunogens were measured and sera were allotyped for several Gm, A2m, and Km antigens. A highly significant association was found between the Km(1) allotype and the immune responses (difference between post-immunisation and pre-immunisation antibody levels) to H. influenzae and meningococcus C polysaccharides in the White children.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Continental Ancestry Group
  • Antibodies, Bacterial / isolation & purification*
  • Bacterial Vaccines / immunology*
  • Diphtheria Toxoid / immunology
  • European Continental Ancestry Group
  • Genes, MHC Class II
  • Haemophilus influenzae / immunology*
  • Humans
  • Immunoglobulins / isolation & purification*
  • Infant
  • Isoantigens / genetics
  • Isoantigens / immunology
  • Neisseria meningitidis / immunology*
  • Pertussis Vaccine / immunology
  • Phenotype
  • Polysaccharides, Bacterial / immunology*
  • Tetanus Toxoid / immunology


  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Diphtheria Toxoid
  • Immunoglobulins
  • Isoantigens
  • Pertussis Vaccine
  • Polysaccharides, Bacterial
  • Tetanus Toxoid