Three small nucleolar RNAs of unique nucleotide sequences

Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):635-8. doi: 10.1073/pnas.90.2.635.

Abstract

Three small RNA species were detected in human cells, and their cDNAs were synthesized and cloned. These RNAs are nucleolar, are 207, 154, and 135 nucleotides long, and are named E1, E2, and E3, respectively, and their unique nucleotide sequences suggest that they may belong to an additional family of small nucleolar RNAs. The 5' ends of these three RNAs do not appear to have a trimethylguanosine cap or another type of cap. Apparent homologs of these three RNAs were detected in mouse, rabbit, and frog cells, suggesting their universal importance. They are housekeeping RNA species, since they are present in all rabbit tissues analyzed.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cell Nucleolus / chemistry*
  • DNA Probes
  • Humans
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • RNA, Small Nuclear / genetics
  • RNA, Small Nuclear / isolation & purification*
  • Sequence Homology, Nucleic Acid
  • Species Specificity

Substances

  • DNA Probes
  • RNA, Small Nuclear

Associated data

  • GENBANK/L07382
  • GENBANK/L07383
  • GENBANK/L07384