Clarithromycin-carbamazepine interaction: a case report

Epilepsia. Jan-Feb 1993;34(1):161-2. doi: 10.1111/j.1528-1157.1993.tb02391.x.


We report a clinically relevant interaction between a new macrolide antibiotic, clarithromycin, and carbamazepine (CBZ). In a patient receiving CBZ monotherapy, 10-day antibiotic treatment increased CBZ concentration despite concomitant CBZ dose reduction and doubled the CBZ concentration/dose ratio. Concentration of the CBZ epoxide (CBZ-E) metabolite was reduced, suggesting that the interaction occurs at a metabolic level.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carbamazepine / pharmacokinetics
  • Carbamazepine / pharmacology*
  • Clarithromycin / pharmacokinetics
  • Clarithromycin / pharmacology*
  • Drug Interactions
  • Drug Therapy, Combination
  • Epilepsies, Partial / drug therapy
  • Humans
  • Lung Diseases / drug therapy
  • Male


  • Carbamazepine
  • Clarithromycin