The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family

FEBS Lett. 1993 Jan 11;315(3):318-22. doi: 10.1016/0014-5793(93)81186-4.


We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25% and 18.5% to the non-NMDA and NMDA receptor subunits, respectively. The rat delta-2 gene is expressed predominantly in Purkinje cells of the cerebellum whereas only low levels of delta-1 transcripts are found in the adult brain. However, delta-1 gene expression undergoes a pronounced developmental peak, with particularly high mRNA levels in the caudate putamen of late embryonic/early postnatal stages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Autoradiography
  • Base Sequence
  • Brain / metabolism
  • DNA
  • In Situ Hybridization
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger / metabolism
  • Rats
  • Receptors, Amino Acid / genetics*
  • Receptors, Amino Acid / metabolism
  • Sequence Homology, Amino Acid


  • RNA, Messenger
  • Receptors, Amino Acid
  • DNA

Associated data

  • GENBANK/X68456
  • GENBANK/X68457
  • GENBANK/X68458
  • GENBANK/X68459
  • GENBANK/X68460
  • GENBANK/X68461
  • GENBANK/X68462
  • GENBANK/X68463
  • GENBANK/Z17238
  • GENBANK/Z17239