The inherent DNase of pyocin AP41 causes breakdown of chromosomal DNA

J Bacteriol. 1993 Feb;175(3):912-5. doi: 10.1128/jb.175.3.912-915.1993.

Abstract

Pyocin AP41 degrades the chromosomal DNA in sensitive strains of Pseudomonas aeruginosa but has little effect on RNA, protein, and lipid syntheses. In vitro experiments showed that the carboxyl-terminal part of the large subunit of pyocin AP41 carries an inherent DNase that is responsible for its killing action.

MeSH terms

  • Amino Acid Sequence
  • Chromosomes, Bacterial / metabolism
  • DNA, Bacterial / metabolism*
  • Deoxyribonucleases / metabolism
  • Molecular Sequence Data
  • Peptide Fragments / metabolism
  • Pseudomonas aeruginosa / metabolism*
  • Pyocins / chemistry
  • Pyocins / metabolism*
  • Trypsin

Substances

  • DNA, Bacterial
  • Peptide Fragments
  • Pyocins
  • Deoxyribonucleases
  • Trypsin