Flow and composition of leg lymph in normal men during venous stasis, muscular activity and local hyperthermia

Acta Physiol Scand. 1977 Feb;99(2):149-55. doi: 10.1111/j.1748-1716.1977.tb10365.x.


Changes in normal human leg lymph protein concentration, output, and lymph flow/lymph protein concentration relationship, as well as lactate dehydrogenase and alkaline phosphatase activity were followed during procedures known to increase capillary filtration as venous stasis, muscular exercise and warming of tissues. Lymph flow increased by 83% during two hour ergometer cycling, and by 117% during two hour warm water foot bath. During a two hour period of venous stasis lymph flow dropped by 50%. There was an increase in lymph flow during the rest period following all three types of experiment, most pronounced after foot warming. An inverse relationship between the lymph flow rate and lymph protein concentration was found. Lymph enzymes followed the same pattern of changes as total protein.

MeSH terms

  • Adult
  • Alkaline Phosphatase / analysis
  • Capillary Permeability
  • Circadian Rhythm
  • Hot Temperature*
  • Humans
  • L-Lactate Dehydrogenase / analysis
  • Leg / blood supply
  • Lymph* / analysis
  • Lymph* / enzymology
  • Lymphatic System / physiology*
  • Male
  • Muscle Contraction
  • Physical Exertion*
  • Proteins / analysis
  • Vascular Resistance


  • Proteins
  • L-Lactate Dehydrogenase
  • Alkaline Phosphatase