Neurosurgical horizons in Parkinson's disease

Neurology. 1993 Jan;43(1):1-7. doi: 10.1212/wnl.43.1_part_1.1.


Based on recent neuroanatomic and physiologic discoveries, neurosurgical therapies may increasingly complement and extend pharmacologic management of Parkinson's disease. Procedures showing promise include subthalamotomy and pallidotomy; thalamic electrical stimulation may also offer application for tremor control. Transplantation of adrenal chromaffin cells has not been associated with consistent long-term improvement in most patients, and fetal mesencephalic transplantation remains controversial. Trophic factors that may be pivotal to cellular repair and survival of transplanted tissue have potential therapeutic roles when purified and perfused centrally or when the cells that produce the factors are transplanted.

Publication types

  • Review

MeSH terms

  • Adrenal Glands / transplantation
  • Animals
  • Brain Tissue Transplantation
  • Combined Modality Therapy
  • Electric Stimulation Therapy
  • Fetal Tissue Transplantation
  • Globus Pallidus / surgery
  • Humans
  • Mesencephalon / transplantation
  • Parkinson Disease / surgery*
  • Thalamus / surgery