Regression of Barrett's esophagus by laser ablation in an anacid environment

Dig Dis Sci. 1993 Feb;38(2):365-8. doi: 10.1007/BF01307557.


Consistent regression of intestinal metaplasia in Barrett's esophagus has not been achieved with medical or surgical interventions. In this case report, a patient with Barrett's esophagus of stable length had half the circumference of the Barrett's epithelium ablated with laser therapy while on a high-dose proton-pump inhibitor. In the absence of esophageal acid exposure and after laser ablation, the intestinal metaplasia was documented to reepithelialize with normal squamous mucosa, which has persisted.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Barrett Esophagus / pathology
  • Barrett Esophagus / therapy*
  • Biopsy
  • Combined Modality Therapy
  • Esophagoscopy
  • Esophagus / pathology
  • Esophagus / surgery*
  • Humans
  • Laser Therapy*
  • Male
  • Metaplasia / pathology
  • Metaplasia / therapy
  • Mucous Membrane / pathology
  • Mucous Membrane / surgery
  • Omeprazole / therapeutic use*
  • Remission Induction


  • Omeprazole