Risk of another basal cell carcinoma developing after treatment of a basal cell carcinoma

J Am Acad Dermatol. 1993 Jan;28(1):22-8. doi: 10.1016/0190-9622(93)70003-c.


Background: There is an increased risk of new basal cell carcinomas (BCCs) developing in a person who has had a BCC.

Objective: This study attempts to define the magnitude of this increased risk.

Methods: The charts of 260 white patients with a histologically proven BCC were reviewed for the occurrence of new BCCs. The cumulative 5-year incidence (modified life-table method) for new BCCs developing in these patients was compared with the 5-year incidence in the general white population of the United States.

Results: Of the 260 patients, new BCCs developed in 137 within an average of 38.3 months, a 5-year cumulative rate of one or more new BCCs of 45.2%. The yearly risk for new BCCs developing in the study population remained high during the 5-year interval. In the general white population of the United States, the maximal 5-year incidence was calculated to be 5% (p < 0.005, chi-square test).

Conclusion: Patients with a history of BCC require life-long follow-up because of the high probability of new BCCs developing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Carcinoma, Basal Cell / epidemiology*
  • Carcinoma, Basal Cell / therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Life Tables
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / epidemiology*
  • Retrospective Studies
  • Risk
  • Skin Neoplasms / epidemiology*
  • Skin Neoplasms / therapy
  • United States / epidemiology