Selenium and oxygen-metabolizing enzymes in elderly community residents: a pilot epidemiological study

J Am Geriatr Soc. 1993 Feb;41(2):143-8. doi: 10.1111/j.1532-5415.1993.tb02048.x.


Objective: To investigate the relationship of selenium and oxygen-deactivating enzymes with age in the elderly.

Sample: The study sample consisted of volunteers recruited from the PAQUID study. This study is conducted in a representative sample of non-institutionalized individuals aged > or = 65 years living in Southwestern France; its main objective is to study longitudinally the incidence and risk factors of dementia.

Methods: Plasma and erythrocyte selenium and activities of oxygen metabolizing enzymes in erythrocytes (GSH-Px, CuZn-SOD, and GSSG-RD) were measured in 239 volunteers (108 males and 131 females; mean age 73.7 years).

Results: Plasma selenium (PSe) decreased significantly with age; a similar but non-significant trend was found for erythrocyte selenium (ESe). None of the enzyme activities showed a clear relationship with age. Women had significantly higher GSH-Px activities than men. For PSe levels lower than 77 ng/mL, there was a strong correlation between PSe and GSH-Px; above this value, the correlation decreased, suggesting that the selenium requirement for GSH-Px production had been satisfied. In this sample, CuZn-SOD was correlated negatively with GSH-Px (r = -0.18; P < or = 0.01) and positively with GSSG-RD (r = +0.20; P < or = 0.01).

Conclusions: In individuals aged > or = 65 years, we found that blood selenium levels were negatively correlated with age. Our analysis of the relationship between selenium and GSH-Px activity suggests that low selenium values are associated with decreased GSH-Px activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / metabolism*
  • Epidemiologic Methods
  • Female
  • Glutathione / metabolism*
  • Glutathione Reductase / metabolism*
  • Humans
  • Male
  • Pilot Projects
  • Selenium / blood*
  • Sex Factors
  • Superoxide Dismutase / metabolism*


  • Superoxide Dismutase
  • Glutathione Reductase
  • Glutathione
  • Selenium