Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue

R Dittadi; P M Donisi; A Brazzale; L Cappellozza; G Bruscagnin; M Gion

doi:10.1038/bjc.1993.2

Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue

Br J Cancer. 1993 Jan;67(1):7-9. doi: 10.1038/bjc.1993.2.

Authors

R Dittadi¹, P M Donisi, A Brazzale, L Cappellozza, G Bruscagnin, M Gion

Affiliation

¹ Center for the Study of Biological Markers of Malignancy, Regional General Hospital, Venice, Italy.

Abstract

Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found.

Publication types

Comparative Study

MeSH terms

Aged
Breast / ultrastructure*
Breast Neoplasms / ultrastructure*
ErbB Receptors / analysis*
Female
Humans
Middle Aged
Receptors, Estrogen / analysis
Receptors, Progesterone / analysis

Substances

Receptors, Estrogen
Receptors, Progesterone
ErbB Receptors