Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue

Br J Cancer. 1993 Jan;67(1):7-9. doi: 10.1038/bjc.1993.2.


Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Breast / ultrastructure*
  • Breast Neoplasms / ultrastructure*
  • ErbB Receptors / analysis*
  • Female
  • Humans
  • Middle Aged
  • Receptors, Estrogen / analysis
  • Receptors, Progesterone / analysis


  • Receptors, Estrogen
  • Receptors, Progesterone
  • ErbB Receptors