The roles of heat shock proteins and immediate early genes in central nervous system normal function and pathology

Curr Opin Neurol Neurosurg. 1993 Feb;6(1):6-10.

Abstract

The expression and transcription of heat shock proteins and immediate early genes in the central nervous system are greatly affected by disease and injury. However, the participation of these genes in both normal and pathophysiologic function is uncertain. Experiments performed this past year shed light on the possible roles of heat shock proteins and immediate early genes in neurologic tissue.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Alzheimer Disease / physiopathology*
  • Brain / metabolism
  • Brain / physiopathology
  • Brain Ischemia / immunology*
  • Brain Ischemia / physiopathology
  • Central Nervous System / physiology*
  • Central Nervous System / physiopathology
  • Female
  • Fever / metabolism
  • Fever / physiopathology
  • Gene Expression / genetics
  • Gene Expression / physiology
  • Heat-Shock Proteins / immunology*
  • Heat-Shock Proteins / physiology*
  • Humans
  • In Situ Hybridization
  • Male
  • Phosphorylation
  • RNA, Messenger / immunology
  • RNA, Messenger / physiology
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / immunology

Substances

  • Heat-Shock Proteins
  • RNA, Messenger
  • Tumor Suppressor Protein p53