The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21

P M Kluck; J Wiegant; R P Jansen; M W Bolk; A K Raap; R Willemze; J E Landegent

doi:10.1007/BF00217455

The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21

Hum Genet. 1993 Jan;90(5):542-4. doi: 10.1007/BF00217455.

Authors

P M Kluck¹, J Wiegant, R P Jansen, M W Bolk, A K Raap, R Willemze, J E Landegent

Affiliation

¹ Department of Hematology, University Medical Center, Leiden, The Netherlands.

PMID: 8428753
DOI: 10.1007/BF00217455

Abstract

The human interleukin-6 receptor alpha chain (IL6R alpha) gene was regionally mapped to chromosome 1 band q21 by fluorescence in situ hybridization. As hybridization probes, partially overlapping lambda clones encompassing 28 kb of the genomic region of the gene were used. These clones were isolated using a polymerase chain reaction (PCR)-generated fragment of the 3' non-coding region of the gene. This localization confirms and extends the provisional assignment of the IL6R alpha gene to chromosome 1, for which a panel of somatic cell hybrids was used.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Pair 1*
Humans
In Situ Hybridization, Fluorescence
Interleukin-6*
Polymerase Chain Reaction
Receptors, Immunologic / genetics*
Receptors, Interleukin-6
Restriction Mapping

Substances

Interleukin-6
Receptors, Immunologic
Receptors, Interleukin-6