Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs

J Am Vet Med Assoc. 1993 Jan 15;202(2):251-6.

Abstract

A randomized, double-blind, controlled study was performed with 18 arthritic dogs administered aspirin (25 mg/kg of body weight, PO, q 8 h) and excipient (control group) or aspirin and misoprostol (100 micrograms, PO, q 8 h). Dogs in the misoprostol (n = 10) and control (n = 8) groups were primarily compared by use of sequential gastroduodenoscopy, changes in PCV, and prevalence of clinical signs of gastrointestinal disturbance over a 14-day treatment period. The misoprostol/aspirin-treated group had significantly (P < 0.05) less gastroduodenal hemorrhage and ulceration and a significantly (P < 0.05) lower prevalence of vomiting than did the control group.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspirin / adverse effects*
  • Aspirin / therapeutic use
  • Diarrhea / chemically induced
  • Diarrhea / prevention & control
  • Diarrhea / veterinary
  • Dog Diseases / chemically induced
  • Dog Diseases / drug therapy
  • Dog Diseases / prevention & control*
  • Dogs
  • Double-Blind Method
  • Duodenoscopy / veterinary
  • Female
  • Gastrointestinal Hemorrhage / prevention & control
  • Gastrointestinal Hemorrhage / veterinary
  • Gastroscopy / veterinary
  • Male
  • Misoprostol / therapeutic use*
  • Osteoarthritis / drug therapy
  • Osteoarthritis / veterinary*
  • Peptic Ulcer / chemically induced
  • Peptic Ulcer / prevention & control
  • Peptic Ulcer / veterinary*
  • Vomiting / chemically induced
  • Vomiting / prevention & control
  • Vomiting / veterinary

Substances

  • Misoprostol
  • Aspirin