Abstract
A randomized, double-blind, controlled study was performed with 18 arthritic dogs administered aspirin (25 mg/kg of body weight, PO, q 8 h) and excipient (control group) or aspirin and misoprostol (100 micrograms, PO, q 8 h). Dogs in the misoprostol (n = 10) and control (n = 8) groups were primarily compared by use of sequential gastroduodenoscopy, changes in PCV, and prevalence of clinical signs of gastrointestinal disturbance over a 14-day treatment period. The misoprostol/aspirin-treated group had significantly (P < 0.05) less gastroduodenal hemorrhage and ulceration and a significantly (P < 0.05) lower prevalence of vomiting than did the control group.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aspirin / adverse effects*
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Aspirin / therapeutic use
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Diarrhea / chemically induced
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Diarrhea / prevention & control
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Diarrhea / veterinary
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Dog Diseases / chemically induced
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Dog Diseases / drug therapy
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Dog Diseases / prevention & control*
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Dogs
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Double-Blind Method
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Duodenoscopy / veterinary
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Female
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Gastrointestinal Hemorrhage / prevention & control
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Gastrointestinal Hemorrhage / veterinary
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Gastroscopy / veterinary
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Male
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Misoprostol / therapeutic use*
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Osteoarthritis / drug therapy
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Osteoarthritis / veterinary*
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Peptic Ulcer / chemically induced
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Peptic Ulcer / prevention & control
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Peptic Ulcer / veterinary*
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Vomiting / chemically induced
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Vomiting / prevention & control
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Vomiting / veterinary