Hypersensitivity to tartrazine (FD&C Yellow No. 5) and other dyes and additives present in foods and pharmaceutical products

Ann Allergy. 1977 Mar;38(3):206-10.


Tartrazine (FD&C Yellow No. 5) and other allowed certified color additives may have an exacerbating effect in chronic urticaria and asthma sufferers. In the individual patient the only way to determine their relevance is to administer test doses. By altering doses, timing and substances and by interspacing controls a battery of tests has been developed. Methods of testing for sensitization to food additives and analgesics are described.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Azo Compounds / adverse effects*
  • Child
  • Coloring Agents / adverse effects*
  • Diet
  • Dose-Response Relationship, Drug
  • Drug Hypersensitivity / diagnosis
  • Drug Hypersensitivity / etiology*
  • Female
  • Food Additives / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Tartrazine / adverse effects*


  • Azo Compounds
  • Coloring Agents
  • Food Additives
  • Tartrazine