Cerebrospinal fluid interferon-gamma is increased in HTLV-I-associated myelopathy

J Neuroimmunol. 1993 Feb;42(2):223-6. doi: 10.1016/0165-5728(93)90014-p.


Serum and cerebrospinal fluid (CSF) levels of interferon-gamma (IFN-gamma) were assayed with an immunoenzymetric method in 16 patients with HTLV-I-associated myelopathy (HAM). IFN-gamma levels were elevated in serum of two patients and in CSF of nine. Although there was no significant association between the clinical features and the CSF IFN-gamma levels, the mean levels of CSF IgG and CSF anti-HTLV-I antibody titer were higher in patients with elevated CSF IFN-gamma levels than in those with normal CSF IFN-gamma levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Female
  • HTLV-I Antibodies / analysis
  • Humans
  • Interferon-gamma / blood
  • Interferon-gamma / cerebrospinal fluid*
  • Male
  • Middle Aged
  • Paraparesis, Tropical Spastic / blood
  • Paraparesis, Tropical Spastic / cerebrospinal fluid*


  • HTLV-I Antibodies
  • Interferon-gamma