Normal hematopoietic reconstitution following ASTA-Z 7557-purged grafts in the absence of in vitro CFU-GM colony growth

Leuk Res. 1993 Jan;17(1):61-7. doi: 10.1016/0145-2126(93)90142-8.

Abstract

Hematopoietic reconstitution was assessed in 26 consecutive patients who underwent autologous bone marrow transplantation (ABMT) with ASTA-Z 7557 purged bone marrows. Of the 26, 17 had acute non-lymphoblastic leukemia (ANLL), 7 had acute lymphoblastic leukemia (ALL), 1 had non-Hodgkin's lymphoma (NHL) and 1 had multiple myeloma (MM). Twelve patients had practically no CFU-GM growth after ASTA-Z treatment. No statistical difference was observed in hematopoietic reconstitution between patients with or without in vitro CFU-GM colony growth. No significant linear correlation was observed between CFU-GM content in the treated graft and day of engraftment. In vitro CFU-GM growth has no predictive value in assessing hematopoietic recovery in vivo. Patients with no CFU-GM growth demonstrated normal engraftment.

MeSH terms

  • Adolescent
  • Adult
  • Antineoplastic Agents / pharmacology*
  • Bone Marrow Cells
  • Bone Marrow Purging / methods*
  • Bone Marrow Transplantation / methods*
  • Child
  • Child, Preschool
  • Cyclophosphamide / analogs & derivatives*
  • Cyclophosphamide / pharmacology
  • Female
  • Hematopoiesis / physiology*
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Leukemia, Myeloid, Acute / therapy
  • Male
  • Middle Aged
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Regression Analysis
  • Transplantation, Autologous

Substances

  • Antineoplastic Agents
  • mafosfamide
  • Cyclophosphamide