201Tl-labelled TlCl dosimetry revisited

Nucl Med Commun. 1993 Feb;14(2):104-7. doi: 10.1097/00006231-199302000-00005.


A review of the literature pertaining to the human dosimetry of 201Tl-labelled thallous chloride provides a spectrum of organ absorbed doses associated with this radiopharmaceutical. A more recent article details human quantitative studies up to 216 h postadministration. This multiorgan radiopharmacological study, however, reports the kidney dosimetry to be significantly lower than previous values; 0.0647 mGy MBq1 (0.238 rad mCi-1) compared to 0.326 mGy MBq-1 (1.2 rad mCi-1). Because of the latter discrepancy the dosimetry was recalculated using the reported pharmacodynamic data. This recalculation resulted in a kidney radiation dose comparable to previously published reports of 0.514 mGy MBq-1 (1.89 rad mCi-1). Also, revised absorbed doses to the various segments of the gastrointestinal tract (GIT) were significantly higher.

Publication types

  • Review

MeSH terms

  • Humans
  • Radiation Dosage
  • Thallium / pharmacokinetics*
  • Thallium Radioisotopes / pharmacokinetics*
  • Tissue Distribution


  • Thallium Radioisotopes
  • thallium chloride
  • Thallium