Tumor suppression in Xiphophorus by an accidentally acquired promoter

Science. 1993 Feb 5;259(5096):816-9. doi: 10.1126/science.8430335.

Abstract

Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologous recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cyprinodontiformes / genetics*
  • Embryo, Nonmammalian
  • Fish Diseases / genetics*
  • Fish Proteins*
  • Gene Library
  • Genes, Tumor Suppressor*
  • Melanoma / genetics
  • Melanoma / veterinary*
  • Molecular Sequence Data
  • Oligodeoxyribonucleotides
  • Oncogenes*
  • Polymerase Chain Reaction / methods
  • Promoter Regions, Genetic*
  • Protein-Tyrosine Kinases / genetics*
  • Proto-Oncogenes
  • Receptor Protein-Tyrosine Kinases*

Substances

  • Fish Proteins
  • Oligodeoxyribonucleotides
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases
  • Xmrk protein, Xiphophorus

Associated data

  • GENBANK/L08396
  • GENBANK/L08397
  • GENBANK/L08398