The Os/+ mouse: a genetic animal model of reduced renal mass

Am J Physiol. 1993 Jan;264(1 Pt 2):F53-60. doi: 10.1152/ajprenal.1993.264.1.F53.

Abstract

The ROP [Ra/+ (ragged), Os/+ (oligosyndactyly), and Pt/+ (pintail)] mouse possessing the gene for oligosyndactylism (Os) was evaluated as a potential genetic animal model of reduced renal mass. Young male ROP mice that were heterozygotes with respect to the Os gene (Os/+) and their normal homozygote litter mates (+/+) were used in the present study. Approximately 50% fewer nephrons were present in the Os/+ mice than in the +/+ mice. Hypertrophic changes were detected in the epithelial cells in proximal convoluted and proximal straight tubules as well as in cortical collecting ducts in the kidneys of the Os/+ mice. Glomerular hypertrophy was also noted in the kidneys of these mice. After unilateral nephrectomy, further hypertrophic changes occurred in both Os/+ and +/+ mice, but the magnitude of compensatory growth was greater in the +/+ mice. From a functional standpoint, the Os/+ mice appeared to be capable of maintaining normal fluid and electrolyte homeostasis, even after unilateral nephrectomy. The findings from the present study indicate that the ROP Os/+ mouse can be a useful animal model to study the effects of reduced renal mass.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Body Weight
  • Hypertrophy
  • Kidney / pathology*
  • Kidney / physiopathology
  • Kidney Glomerulus / pathology
  • Kidney Tubules / pathology
  • Male
  • Mice
  • Mice, Mutant Strains / anatomy & histology*
  • Nephrectomy*
  • Organ Size
  • Postoperative Period
  • Reference Values